王长号 教授（博士生导师）

毕业学校：陕西师范大学（本科），中国科学院大连化学物理研究所（博士）

电     话：致知楼1248室

电子邮箱：changhaowang@snnu.edu.cn

研究方向：人工金属核酸酶的催化功能；功能材料的表界面化学

讲授课程：

人个简介：

一、教育和工作经历

2021-至今 陕西师范大学化学化工学院 教授（破格）

       2017-2020          陕西师范大学化学化工学院 副研究员/副教授  

       2015-2017          德国康斯坦茨大学 博士后 合作导师：Prof. Jörg S. Hartig

       2013-2015          美国马里兰大学帕克分校 博士后 合作导师：Prof. Herman O. Sintim

       2006-2013          中国科学院大连化学物理研究所 博士 导师：李灿 院士

       2002-2006          陕西师范大学化学与材料科学学院 学士

二、研究兴趣

（1）研究环二核苷酸、G-四链体、i-motif等新型核酸的化学生物学功能，特别是其空间构型和其催化性能之间的构效关系。旨在通过研究核酸的催化性能，揭示核酸在自然界中潜在的新功能。

（2）研究仿生体系、生物医用材料等的表界面化学行为，特别是催化性能和应用功能。旨在通过研究上述体系，开发简单、实用、高效、功能性的仿生/医用材料，促进产学研的良性发展。

三、学生培养  

       (1) 在读研究生

顾由琨 邬佩哲 张文阅 杨礼冰 张卓琳

            19级硕士生                   19级硕士生               19级硕士生(联培)               20级硕士生                   20级硕士生

延边大学 内蒙古师范大学 山东师范大学 内蒙古大学 陕西师范大学

        ykgu@snnu.edu.cn      wupeizhe@snnu.edu.cn      zwy@snnu.edu.cn         lbyang@snnu.edu.cn   zhuolinzhang@snnu.edu.cn

刘莉 刘伟 王梓潇 秦玮骏

             20级硕士生                   21级硕士生                   21级硕士生                   21级硕士生

青海大学 陕西师范大学 东北师范大学 忻州师范学院

          liliu@snnu.edu.cn  qq1328135359@snnu.edu.cn   zxwang@snnu.edu.cn    weijunqin@snnu.edu.cn

       (2) 已毕业的研究生

       (3) 参与大学生创新创业项目的本科生

             2021年大学生创新创业项目：李嘉琦、龙亚洁、安雨桐、卫郑伟

             2019年大学生创新创业项目-国家级重点：伍文婧、董春博、任雨欣、张文舒、程庆雯

             2018年大学生创新创业项目-国家级重点：袁梓健、曲瑶、裴雪、高雨欣

       (4) 在本组完成学位论文的本科生

            2021届：刘伟、任雨欣、程庆雯

             2020届：曲瑶、高雨欣

             2019届：李静、裴玉娟

             2018届：熊令、高换换

四、学术/教学奖励

       2021年：陕西师范大学课堂教学创新大赛（一等奖）

       2019年：陕西师范大学青年教师教学基本功大赛（二等奖）

       2013年：中国科学院院长奖（优秀奖）

       2012年：林励吾催化奖（优秀博士生奖）

五、承担科研项目情况

  [7] 国家自然科学基金-面上项目, “环状RNA人工金属酶主客体相互作用及手性催化构效关系”, 22072080, 2021.01-2024.12.    

  [6] 中央高校基金自由探索-重点项目, “人工金属核酸酶的精准构建及其手性催化性能”, GK202102002, 2021.01-2023.12.  

  [5] 陕西师范大学化学化工学院-腾飞计划学者项目, “人工核酸酶的催化性能研究”, 2021.01-2023.12.    

  [4] 陕西省自然科学基金-青年项目, “CDN人工金属酶的组装及其手性催化功能研究”, 2019JQ161, 2019.01-2020.12.

  [3] 留学人员科技活动择优支持项目-优秀类, “环二核苷酸的催化功能研究”, 2018008, 2018.10-2020.09.

  [2] 中央高校基金自由探索-重点项目, “环二核苷酸的手性催化功能研究”, GK201802001, 2018.01-2020.12.

  [1] 国家自然科学基金-青年项目, “环二鸟苷酸的手性催化功能研究”, 21703132, 2018.01-2020.12.  

六、承担教学情况

本科生课程：《物理化学》、《基础物理化学实验》、《物理化学研究进展和前瞻》

研究生课程：《科技论文写作》（全英）

代表性成果：

[32] Xingchen Dong,^# Zijian Yuan,^# Yao Qu, Yuxin Gao, Xue Pei, Qianqian Qi, Yujuan Pei, Jiaqi Li, Yashao Chen and Changhao Wang*, An ATP–Cu(II) catalyst efficiently catalyzes enantioselective Michael reactions in water. Green Chem., 2021, 23, 9876-9880. (# equal author)

[31] Nini Li, Xiaohong Ji, Bulei Wang, Yanglin Guo, Changhao Wang* and Yashao Chen*, Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection. Mater. Sci. Eng. C, 2021, 128, 112346.

[30] Nini Li,^# Le Yun,^# Xiaohong Ji, Somnath Mukherjee, Changhao Wang* and Yashao Chen*, Construction of photoresponsive azobenzene-decorated cationic surfactant-based self-assembled vesicles and controlled drug release. Colloids Surf. A., 2021, 631, 127711. (# equal author)

[29] Changhao Wang,^#,* Qianqian Qi,^# Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen and Jörg S. Hartig, A Cu(II)-ATP complex efficiently catalyses enantioselective Diels-Alder reactions. Nat. Commun., 2020, 11, 4792. (# equal author)

[28] Changhao Wang,^#,* Min Hao,^# Qianqian Qi, Jingshuang Dang, Xingchen Dong, Shuting Lv, Ling Xiong, Huanhuan Gao, Guoqing Jia, Yashao Chen*, Jörg S. Hartig and Can Li, Highly efficient cyclic dinucleotide based artificial metalloribozymes for enantioselective Friedel-Crafts reactions in water. Angew. Chem. Int. Ed., 2020, 59, 3444-3449. (# equal author)

[27] Jing Zhang,^# Nini Li,^# Dongmei Zhang, Mengjin Dong, Changhao Wang* and Yashao Chen*, Construction of cinnamic acids derived β-cyclodextrins and their emodin-based inclusions with enhanced water solubility, excellent antioxidant and antibacterial activities, Colloids Surf. A., 2020, 606, 125382. (# equal author)

[26] Qianqian Qi, Shuting Lv, Min Hao, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen* and Changhao Wang*, An efficient cyclic di-AMP based artificial metalloribozyme for enantioselective Diels-Alder reactions. Eur. J. Org. Chem., 2020, 2020, 4417-4424.

[25] Hongkai Wang,^# Weihuang Zhu,^# Qi Xue, Changhao Wang* and Kaiqiang Liu*, Solvent dispersion triggered the formation of NiFe-gel as an efficient electrocatalyst for enhancing the oxygen evolution reaction. Chem. Commun., 2020, 56, 7781-7784. (# equal author)

[24] Wancheng Zhu, Liu Jiang, Bulei Wang, Shunli Gu, Fenyan Hu, Changhao Wang* and Yashao Chen*, Rational design of PMPC/PDMC/PEGDA hydrogel micropatterns onto polylactic acid with enhanced biological activity. ACS Biomater. Sci. Eng., 2020, 6, 3799-3810.

[23] Dongmei Zhang, Guanke Cai, Somnath Mukherjee, Yajuan Sun, Changhao Wang, Bingjie Mai, Kaiqiang Liu, Cheng Yang* and Yashao Chen*, Elastic, persistently moisture-retentive, and wearable biomimetic film inspired by fetal scarless repair for promoting skin wound healing, ACS Appl. Mater. Interfaces, 2020, 12, 5542-5556.

[22] Dongmei Zhang, Bulei Wang, Yajuan Sun, Changhao Wang, Somnath Mukherjee, Cheng Yang* and Yashao Chen*, Injectable enzyme-based hydrogel matrix with precisely oxidative stress defense for promoting dermal repair of burn wound, Macromol. Biosci., 2020, 20, 2000036.

[21] Minting Du,^# Mengke Peng,^# Bingjie Mai, Fenyan Hu, Xiaodan Zhang, Yashao Chen* and Changhao Wang*, A multifunctional hybrid inorganic-organic coating fabricated on magnesium alloy surface with antiplatelet adhesion and antibacterial activities, Surf. Coat. Tech., 2020, 384, 125336. (# equal author)

[20] Mengke Peng, Fenyan Hu, Minting Du, Bingjie Mai, Shurong Zheng, Peng Liu, Changhao Wang* and Yashao Chen*, Hydrothermal growth of hydroxyapatite and ZnO bilayered nanoarrays on magnesium alloy surface with antibacterial activities, Front. Mater. Sci., 2020, 14, 14-23.

[19] Changhao Wang*, Min Hao, Qianqian Qi, Yashao Chen and Jörg S. Hartig*, Chemical synthesis, purification, and characterization of 3’-5’-linked canonical cyclic dinucleotides (CDNs). Method Enzymol., 2019, 625, 41-59.

[18] Liu Jiang, Wancheng Zhu, Huaming Qian, Changhao Wang*, Yashao Chen* and Peng Liu*, Fabrication of PMPC/PTM/PEGDA micropatterns onto polypropylene films behaving with dual functions of antifouling and antimicrobial activities. J. Mater. Chem. B, 2019, 7, 5078-5088.

[17] Mengke Peng, Xiaodan Zhang, Xiao Xiao, Mengjin Dong, Guowei Zhao, Peng Liu, Yashao Chen* and Changhao Wang*, Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities. J. Coat. Technol. Res., 2019, 16, 857-868.

[16] Sebastian Knorr,^# Malte Sinn,^# Dmitry Galetskiy, Rhys M. Williams, Changhao Wang, Nicolai Müller, Olga Mayans, David Schleheck and Jörg S. Hartig*, Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat. Commun., 2018, 9, 5071. (# equal author)

[15] Dongmei Zhang, Cheng Yang*, Ziru Niu, Changhao Wang, Somnath Mukherjee, Dan Wang, Xi Li, Ruiqi Liu, Jin Gao and Yashao Chen*, Construction of crowning β-cyclodextrin with temperature response and efficient properties of host–guest inclusion. Langmuir, 2018, 34, 11567-11574.

[14] Jie Yang, Le Yun, Guowei Zhao, Feng Zhang, Yashao Chen* and Changhao Wang*, Fabrication of pH-responsive system based on cationic gemini surfactant/sodium octanedioate and its application on controlled release of paclitaxel. Colloids Surf. A., 2018, 539, 101-108.

[13] Changhao Wang, Malte Sinn, Julia Stifel, Anna C. Heiler, Annette Sommershof and Jörg S. Hartig*, Synthesis of all possible canonical (3´-5´-linked) cyclic dinucleotides and evaluation of riboswitch interactions and immune-stimulatory effects. J. Am. Chem. Soc., 2017, 139, 16154-16160.

[12] Xiaochu Ma,^# Jie Zhou,^# Changhao Wang,^# Brandon Carter-Cooper, Fan Yang, Elizabeth Larocque, Jonathan Fine, Genichiro Tsuji, Gaurav Chopra, Rena G. Lapidus and Herman O. Sintim*, Identification of new FLT3 inhibitors that potently inhibit AML cell lines, via an azo click-it/staple-it approach. ACS Med. Chem. Lett., 2017, 8, 492-497. (# equal author)

[11] Changhao Wang, Brandon Carter-Cooper, Yixuan Du, Jie Zhou, Musabbir A. Saeed, Jinbing Liu, Min Guo, Benjamin Roembke, Clinton Mikek, Edwin A. Lewis, Rena G. Lapidus and Herman O. Sintim*, Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities. Eur. J. Med. Chem., 2016, 118, 266-275.

[10] Yinghao Li, Changhao Wang, Jingya Hao, Mingpan Cheng, Guoqing Jia* and Can Li*, Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels-Alder reaction: An unexpected inversion of enantioselectivity modulated by K⁺ and NH₄⁺ ions. Chem. Commun., 2015, 51, 13174-13177.

[9] Yinghao Li, Mingpan Cheng, Jingya Hao, Changhao Wang, Guoqing Jia* and Can Li*, Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme. Chem. Sci., 2015, 6, 5578-5585.

[8] Yinghao Li,^# Guoqing Jia,^# Changhao Wang, Mingpan Cheng and Can Li*, Higher-order human telomeric G-quadruplex DNA metalloenzymes enhance enantioselectivity in Diels-Alder reaction. ChemBioChem, 2015, 16, 618-624. (# equal author)

[7] Changhao Wang, Guoqing Jia, Yinghao Li, Sufang Zhang and Can Li*, Na⁺/K⁺ switch of enantioselectivity in G-quadruplex DNA-based catalysis. Chem. Commun., 2013, 49, 11161-11163.

[6] Changhao Wang, Yinghao Li, Guoqing Jia, Shengmei Lu, Yan Liu and Can Li*, DNA catalyzed dithioacetalization in water. Acta Chim. Sinica, 2013, 71, 36-39.

[5] Yinghao Li, Changhao Wang, Guoqing Jia, Shengmei Lu and Can Li*, Enantioselective Michael addition reactions in water using a DNA-based catalyst. Tetrahedron, 2013, 69, 6585-6590.

[4] Changhao Wang, Guoqing Jia, Jun Zhou, Yinghao Li, Yan Liu, Shengmei Lu and Can Li*, Enantioselective Diels−Alder reaction with G-quadruplex DNA-based catalysts. Angew. Chem. Int. Ed., 2012, 51, 9352-9355.

[3] Changhao Wang, Yinghao Li, Guoqing Jia, Yan Liu, Shengmei Lu and Can Li*, Enantioselective Friedel−Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme. Chem. Commun., 2012, 48, 6232-6234.

[2] Shi Qiu,^# Guanna Li,^# Peng Liu, Changhao Wang, Zhaochi Feng* and Can Li*, Chirality transition in the epoxidation of (-)-α-pinene and successive hydrolysis studied by Raman optical activity and DFT. Phys. Chem. Chem. Phys., 2010, 12, 3005-3013. (# equal author)

[1] Peng Liu, Changhao Wang and Can Li*, Epoxidation of allylic alcohols on self-assembled polyoxometalates hosted in layered double hydroxides with aqueous H₂O₂ as oxidant. J. Catal., 2009, 262, 159-168.